Upon vigorous validation and improvement, the current model can potentially be applied to integrate preclinical and clinical data, and ultimately aid the risk assessment of immunogenicity for therapeutic proteins.
Responses to the women's walking and moderate activity questions were combined to calculate time in non-vigorous exercise and a MET value of 3 was applied to the responses for non-vigorous activity from both men and women.
In a typical fabrication experiment, the as-treated MWCNTs (100 mg) were dispersed in BaTiO3 sol solution by ultrasonication for 30 min, and then vigorous stirring was applied to the mixture suspension for reaction at 40°C for 4 h.
The most vigorous single particle processing of a 2D crystal was applied to vitrified ordered arrays of the Na+/K+-ATPase from dog kidney.
Participants were instructed to pedal as fast as possible for ~2 s before the load is applied and to continue to crank while being provided with vigorous verbal encouragement throughout each sprint.
This could lead to a potential bias of the estimates because relatively less vigorous exclusion was applied in the earlier years than in late years during the period from 2004 to 2008.
There were no significant differences between adolescents with missing data and participants included in data analyses in age, sex, socioeconomic status, perceived neighborhood disorder, moderate-to-vigorous physical activity, or BMI, so no imputation was applied.
The disease course in RA is highly variable and this commonly used step-up therapeutic strategy implies that a proportion of newly diagnosed RA patients are insufficiently treated for a specific time, resulting in the development of erosions that might have been prevented if a more vigorous treatment strategy had been applied.
The exercise training principles of progression and overload were applied for every training component, 42 and they were adapted to each participant's abilities such that a moderate to vigorous intensity was achieved.
Briefly, TA pellets were suspended in 200 μl of sterile phosphate buffered saline by vigorous vortexing, then digested in proteinase K and applied to silica gel spin columns.
