Sentence examples for be applied to mutations from inspiring English sources

This means that the classic genotype – phenotype concept cannot be applied to mutations in many housekeeping genes since the resulting phenotype would depend on p53.

The strength of positional cloning is that it can be applied to mutations derived from almost any source (e.g., transposon, chemical, radiation, natural variation), as long as that mutation defines a locus that can be mapped.

Several defined mixtures of the respective wild-type and mutated constructs ranging from 0 to 100% were applied to mutation-specific PCR and subsequently quantified as described for the patient samples.

Each element in the chromosome is applied to mutation with a predefined mutation probability.

This suggests that once the third most common pathways involving single mutations have been realized, the same evolutionary principles can be applied to double mutations starting with double mutations in negative regulators, followed by double mutations in one negative regulator and one promoter mutation.

We suggest that a similar logic could be applied to proteotoxic mutations.

A similar approach can be applied to other founder mutations in regions not screened for in this study.

The work can also be applied to EFSM based mutation testing to distinguish the initial configuration of a given specification machine from the initial configuration of a mutant EFSM derived from the specification, with respect to some selected types of faults as described in (Bochmann & Petrenko 1994).

Such efforts are underway in myotonic dystrophy and will soon be applied to the C9 mutation.

The same principle can be applied to variations in mutation rates across lineages where the pattern of sequence evolution will provide information about the selective forces acting on the sequence.

Other methodologies such as forced RFLP and sequencing of multiple cloned products could be applied to determine if these mutations are homozygous or heterozygous.