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By defining the core molecular changes downstream of the Cav1.2 mutation and its transcriptional regulators, this work illustrates how an integrative approach can be applied to functionally characterize transcriptional co-regulation under physiological and disease states, and to generate hypotheses to drive further mechanistic experimental investigation.
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This frequency-field calibration can be applied to quantify functionally relevant electric fields at the active site of enzymes.
The model can be applied to any functionally graded plate or sandwich panel with graded core as long as the through thickness stiffness variation can be described by a smooth function.
These facts imply that the proposed method can be applied to suggest possible functions for functionally-unknown or hypothetical proteins, which are increasing rapidly because of many high throughput structural genomics efforts.
Using an example, we show how this approach can be applied to quickly describe and functionally simulate a heterogeneous dataflow-based application.
Finally our approach of screening the IgM+ memory repertoire could be applied to identify conserved and functionally relevant targets on other rapidly evolving pathogens.
Similar results were obtained upon expression of a recombinant fragment of the ErbB2/HER2 receptor protein or GST as MBP fusions, indicating that this approach can generally be applied to enhance secretion and yields of functionally active recombinant proteins.
This approach can further be applied to discovering relationships between the pathogenicity of these organisms to functionally related proteins.
Mass spectrometry, proteomics or similar expression monitoring technologies could be applied to identify particular genes or pathways that are functionally activated during typhoid.
This result suggests that words and rules may be tracked in parallel, by engaging functionally different mechanisms that could be applied to the speech signal simultaneously.
Metabolic sub-network extraction can be applied to predict metabolic pathways for an organism whose genes are functionally annotated but whose metabolism is not yet known.
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