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I then outline a method for guiding decisions concerning the number of repeat measures and deduce several rules of thumb that can be applied in trial design.
While there is no gold standard for the measurement of tremor severity in patients with MS, better normative data about how tremor severity relates to QOL in patients with MS could be applied in trial design for potential therapeutic interventions.
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While we do not suggest this is the final model to be applied in trials, biomarker discovery and genetic studies, the challenge is to characterise further the classes we have identified.
HHFNC needs a thorough investigation before this type of NIV can be applied in trials.
Although the authors of a Cochrane Review on seclusion and mechanical restraint concluded that "there is a surprising and shocking lack of published trials" on coercive interventions in psychiatry, there are only few instruments that can be applied in trials.
While epidemiological evidence for these protective factors is quite strong, evidence that adopting them is effective in preventing AD is less sound or even negative, probably because they have been applied in trials too late in the course of the disease and for too short a period of time.
Therefore, not only will this event based approach be applied in this trial, also a symptom based approach will be used.
The block randomisation method will be applied in this trial and the blind code will be generated by a statistician from Rundo International Pharmaceuticals Research & Development Co, Ltd. with SAS V.9.2.2.
Easy adjustments with no or minor cost could be applied in 71 trials (50%), resulting in 17 trials (12%) changing to low risk for all domains.
It is now critical to set standards for validation in the field so that promising biomarkers can be applied in clinical trials and clinical practice.
Subclass-specific markers based on microarray approaches have been identified and validated by immunohistochemistry [ 86, 87], but have yet to be applied in clinical trials and clinical practice.
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