When the trees were 6 8 years of age, three treatments were applied in randomised complete block designs: an unthinned control, 550 and 300 stems per hectare residual stocking.
Although multi-attribute utility measures have been applied in randomised controlled trials of maternity interventions [ 20, 21, 49, 50], no previous study, to our knowledge, has directly assessed the psychometric properties of these measures in the maternity context.
It is not known how knowledge from intensive interventions of randomised clinical trials can be applied in various real-life clinical settings with limited resources.
By limiting movement of the distal actuator platform, three different foot conditions (forward, free, and restricted) were applied in a randomised block design.
The treatments, comprising additions of 0, 1, 3 or 6 Mg of granulated wood-ash ha−1, were applied in a randomised block design, replicated three times.
An anti-IL-6 monoclonal antibody, siltuximab, has been applied in a randomised phase II study (CNTO 328) in metastatic castration-resistant PCa treatment [ 38].
The randomised treatment was applied in the debridement phase: this ended either when debridement occurred or when treatment was stopped before debridement (classified as withdrawal from trial treatment).
Therefore, a randomised effects model for meta-analysis was applied in order to minimise the effect of clinical heterogeneity.
Nevertheless, in the past years, the number needed to treat has become a well-known effect measure and is conventionally applied in randomised controlled trials (RCTs) with a binary outcome where the duration of follow-up time is fixed and the time to event plays no role or is ignored [ 12].
Intention-to-treat analysis will be applied to include all randomised participants.
