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The pathophysiology of sepsis and its complications remains uncertain as much caution has to be applied in extrapolating to clinical sepsis results obtained in rodent models which have their own inherent complexities [131 134].
Given the great phylogenetic distance between these species caution must be applied in extrapolating biological meaning to these differences.
In the meantime, we suggest that caution be applied in extrapolating findings in murine models to septic patients, both with regard to our understanding of pathophysiology and the failure to translate preclinical efficacy into successful clinical trials.
It also noted that a margin of safety of 100 could be applied in extrapolating animal data to humans to account for species differences in susceptibility, numerical differences in population ranges between the test animals and the human population, the greater variety of complicating disease processes in the human population, and the possibility of synergistic action among food additives.
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The model can be used to design and refine in vitro experiments and extrapolate in vitro effective concentrations to in vivo doses that can be applied in risk assessment.
A multi-model inference approach based on the Akaike Information Criterion was used and the resulting model was applied in a GIS framework to extrapolate predicted richness/likelihood of occurrence across the entire area of the study.
The methodology was applied in both a simulated version and an experimental mock-up of the conveyor belt implementation for a specific food sample, but can be extrapolated to any type of sample.
Although our current findings provide new insights on the mechanisms by which good-quality OO, i.e. polyphenols rich-EVOO, might contribute to lower breast cancer risk in a HER2-dependent manner, extreme caution must be applied when extrapolating in vitro results into clinical practice.
Caution should be applied when extrapolating these data to the whole genome.
For design we suggest that the minimum diameter in the absence of pressure gradient should be measured and our equation is to be applied to extrapolate to the real situation with a finite pressure gradient.
And how he realized how lessons from his own life, and his own management ideas, could help make folks happier, notably how theories of causation, extrapolated from business problems, could be applied to -- in his own word -- happiness.
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