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This strategy can be applied in combinatorial chemistry; therefore, those compounds would be applicable as useful tools in the development of new drugs.
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It has mostly been applied in combinatorial problems inside particular methods.
While the latter sets of sequences have been specifically designed for application in multi-user communication contexts, De Bruijn sequences come from combinatorial mathematics, and have been applied in completely different scenarios.
In general, if m drugs are applied in the course of the therapy, we have 2m combinatorial resistance types.
Various selection strategies have been applied in the past and one approach that has proved effective is the use of combinatorial optimisation methods.
In addition, the biclustering framework of SS-CoSBI can also be applied to study combinatorial binding of multiple transcription factors in enhancers.
Finally, MAXCOM could potentially be applied to find combinatorial protein targets and then help design network drugs.
We then show that our randomized rounding technique can be applied to some problems in combinatorial optimization and operations research.
Recently, the capability of solvers has increased such that ASP started to be applied to solve hard combinatorial problems arising in bioinformatics and systems biology.
Since our approach is generalized and can be applied to solve different types of combinatorial problems, it would be interesting to consider different problems with various components of uncertainty and differing cost structures in future research.
Consequently, we are hereby providing an example of how combinatorial HCS can be applied to provide both descriptive and mechanistic toxicity data in a time- and resource-saving format.
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