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Moreover, the positional correlation and factor analysis embedded in ARTADE2 successfully detected regions at which alternative isoforms may exist, and thus are expected to be applied for discovering transcript biomarkers for a wide range of disciplines including preemptive medicine.
In fact, such genetic selections can be applied for discovering new synthetic riboswitches that activate translation in response to a compound of interest starting form a library of mutant riboswitches; the latter could be mutants of natural riboswitches or even designed in silico (Avihoo et al., 2007).
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An evolutionary optimisation procedure combined with high-throughput synthesis and testing has been applied for discovering new catalytic materials for the oxidative dehydrogenation of ethane to ethylene (ODHE).
An Apache Hadoop cloud computing platform was implemented for decreasing computation time, and pathway information from the KEGG was applied for discovering meaningful biological correlations.
Three microarray data sets of breast cancer were collected from the Gene Expression Omnibus, and pathway information from the Kyoto Encyclopedia of Genes and Genomes was applied for discovering meaningful biological correlations.
Three microarray data sets of breast cancer were collected from the Gene Expression Omnibus (GEO), and pathway information from the Kyoto Encyclopedia of Genes and Genomes (KEGG) was applied for discovering meaningful biological correlations.
From this, appropriate epidemiological and statistical measures should be applied for determining whether a newly discovered marker or panel of markers adds value to pre-existing clinical regimes of risk prediction, diagnosis and prognosis.
There have been several recent examples where this technique has been applied for the purpose of discovering the etiological agent of an outbreak [38], [39], [40], [41].
This approach was applied, for example, by Borisy et al., who discovered new activities using a systematic screening method for identifying effective two-component drug combinations [ 9].
The Benjamini and Hochberg false discover rate (FDR) of 0.01 was applied for multiple testing of significant SNPs.
The distinctive advantage of BNKL - its utility in discovering differentially expressed regulations between comparable conditions - has been applied for discriminating cancer sub-types.
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