Therefore, these STEs may not be applicable to trials that require subjects in all arms to be randomised to an anti-hypertensive drug, or to trials of homogeneous populations, for example, trials of only heart or renal failure patients.
The review aims to identify the analytical methods currently employed or suggested for evaluating healthcare resource use and costs that are likely to be applicable to randomised trial data.
First, the procedure must be able to structure the relationships among prognostic factors and behavioural outcome in a fully automatic manner (as for classifiers built using data mining – in line with Figure 2a) since it should be applicable to any trial without requiring human expertise during the randomization procedure.
However, previous literature has raised possibilities for this discrepancy that may be applicable to donepezil trials.
Conversely, "low risk conditions" may not be applicable to exploratory trials, which are aimed at increasing our understanding the potential therapeutic effects of a new drug.
That review was not restricted to research exclusively within randomised trials and covered both healthcare and non-healthcare settings and it is difficult to know which of these strategies would be applicable to randomised trials in health care.
As the questionnaire was intended to be used across different clinical trials, we developed question items that aimed to be applicable to most clinical trials and yet specific to individual trials.
The findings thus may not be applicable to the clinical trial setting where solid tumours are often large in size (average approximately 30 40 mm) and can originate from, and spread to, any organ, especially the lungs, liver and lymph nodes.
However these findings may only be applicable to the particular trials and settings studied.
Our findings may not be applicable to the entire clinical trial research community, although these high impact studies are likely to address important clinical questions that can potentially affect clinical decision making exactly the type of data whose scientific value should be maximised for public benefit.
