Our findings show that there is a prognostic difference in expression between the two compartments.
In order to determine if there was a prognostic difference between the RT-qPCR and IHC we included both methods in a Cox proportional hazards model and showed that gene expression remained significant in the multivariate analysis and replaced IHC.
Multivariate analyses did not identify any prognostic differences associated with ILC or IDC.
When we defined the Aurora A gene amplification and protein expression as either positive or negative, in contrast to Aurora A mRNA expression, there was no prognostic difference between the Aurora A gene amplification and non-amplification groups, and the Aurora A protein positive and negative groups.
There was significant prognostic difference in survival between CK18-positive and -negative groups according to pStage II (5-year DFS: 33.6% vs 70.6%, respectively, P=0.033) and pStage III (5-year DFS: 27.8% vs 67.9%, respectively, P=0.006), but not at pStage I (5-year DFS: 100% vs 92.3%, respectively, NS) or pStage IV (5-year DFS: 18.2% vs 35.0%, respectively, P=0.579).
The overall 5-year survival of patients with endometrial cancer is around 80%, but there is a substantial prognostic difference depending on stage, myometrial invasion, and histological type[ 39 ].
They commented that CK20 was an independent factor related to prognosis, however, there was no significant prognostic difference between the intestinal type and the pancreaticobiliary type.
There was a significant prognostic difference between patients at stage IIB and IIC (P < 0.001).
There is no significant prognostic difference between the patients with the tumour diameter less than 1 cm and those with the tumour diameter more than 1 cm (P=0.40).
In GGP with single copy MYCN (GGPs) subtypes, there was no significant prognostic difference between the presence and absence of pleomorphic cells (OS, 38% vs 50%, P = 0.481).
