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This suggests that apoptosis might be an underlying pathogenic mechanism of Cre-induced myocardial fibrosis.
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While research has largely focused on inflammatory mechanisms for initiating the fibrotic response, recent evidence strongly suggests that disruption of the alveolar epithelium is an underlying pathogenic event.
20, 24, 48 While some patients with Morgellons disease do demonstrate behavioral aberrancies including a delusional component, many do not, and psychiatric manifestations are possibly from an underlying pathogenic process.
As fibrillogenesis is a common feature of AD and PD, in which a role of ANG has been envisaged, and as fibrillogenesis is an underlying pathogenesis of ApoA-I-related amyloidosis, we hypothesized that pathogenic ApoA-I may suppress ANG expression and that a decrease in ANG level may be a mechanism by which amyloidogenic ApoA-I induce cell death.
There was an underlying deep physical attraction.
There is an underlying rumbling for change.
There's an underlying theme here".
"It's an underlying change.
But there is an underlying tension.
"There's an underlying neurosis about American power," he said.
It is widely believed that MS is an immune-mediated disease whose clinical manifestations and course, as well as response to therapy appear to be heterogeneous, as may be the underlying pathogenic mechanisms [1].
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