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In the context of ex vivo expansion of human islet beta cells for eventual use in cell therapy of diabetes, this dedifferentiation may be an unavoidable price to pay for increasing cell mass.
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But many apartment dwellers believe — incorrectly, in many cases — that tainted air is an unavoidable price of living on top of one's neighbors.
In order to account for the heterogeneity we used a (partially) random-effect model, and the heterogeneity results in wide confidence intervals, which should simply be treated as an unavoidable price to pay.
From the above arguments, I conclude that, even if inbreeding is not immediately advantageous, it is an absolute requirement, an unavoidable price to pay, for long term survival of the descendants.
We hypothesize that this withdrawal is best achieved during tightly controlled sleep periods, which are thus viewed as an unavoidable price of prolonged neuromodulator-driven arousal.
It's a question which has never been more relevant, because all over the globe, nature is being trashed – the mammoth forest fires in Indonesia I wrote about last week are just the most egregious recent example, and it's easy to end up with the despairing sense that the destruction of the natural world is an unavoidable part of the price we pay for human development.
A spokesman for the company, Ian Ailles, said: "We've worked hard to keep the impact of the rising fuel costs on our holidaymakers to a minimum but the fuel levy is an unavoidable result of the rising price of oil".
But grieving is an unavoidable part of life — the necessary price we all pay for having the ability to love other people.
Walters says that price difference is an unavoidable consequence of the quality improvements and giving the Tianlang factory workers overtime pay and vacation time.
Brown is an unavoidable subject.
This is an unavoidable tightrope.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com