Sentence examples for be an initial event from inspiring English sources

These observations suggest that altered properties or lack of the inner colon mucus layer may be an initial event in the development of colitis.

Since ROS production by mitochondria is responsible for major mechanisms involved in diabetic complications, methylglyoxal-induced ROS production may be an initial event in the pathogenesis of vascular complications.

However, RARB and RASSF1A gene methylation appears to be an initial event in urinary bladder carcinogenesis and should be considered as defining a panel of differentially methylated genes in this neoplasia in order to maximize the diagnostic coverage of epigenetic markers, especially in studies aiming at early recurrence detection.

It has been proposed that a fraction of T-ALLs that present as leukemia without evidence of thymic involvement may originate from bone marrow progenitors that have acquired a Notch1 mutation, suggesting that constitutive active Notch1 could, in some cases, be an initial event driving tumor development.

The methylation of RARB and RASSF1A genes appears to be an initial event in urinary bladder carcinogenesis maintained during tumor progression and should be included in the panels of differentially methylated genes in urinary bladder cancer in order to maximize the diagnostic coverage of epigenetic markers.

Swelling of cartilage, which is proportional to the amount of collagen damage, is an initial event of cartilage degeneration, so damage to the collagen fibril network is likely to be one of the earliest signs of OA cartilage degeneration.

14, 15 This is an initial event and a prerequisite for liver injury in this model.

Hence, it seems likely that Atg32-Atg11 isterantinitialan initial event distinct from autophagosome formation.

We here show that activation of p42/44 by HOCl HDL is an initial event in this cascade.

There is no doubt that the 'female suppressing' functions of the Y chromosome in male C. grandis is an initial event towards the establishment of the sexual dimorphism.

Inactivation of the adenomatous polyposis coli (APC) suppressor gene is an initial event in the development of most colorectal tumours (Kinzler and Vogelstein, 1996).