Sentence examples for be an indirect target from inspiring English sources

Our ChIP-qPCR results suggest that FOXM1 protein binds directly to the promoter of CEP55 (Fig. 7I) but not HELLS (Fig. 7J) indicating that CEP55 is a direct transcriptional target of FOXM1, whilst HELLS may be an indirect target.

Genome size may be an indirect target of selection due to its association with cell volume.

Downstream targets have not been identified, although IGFBP-5 may be an indirect target of both Stat3 and IRF-1.

Since, PAK1 emerged as a common mediator linking cellular mechanisms disrupted by 5-ASA; it is also likely to be an indirect target of 5-ASA.

The authors also found that antagonizing miR-21 caused apoptosis in MCF-7 cells, which was associated with lower expression of Bcl-2 protein in the anti-miR-21-transfected MCF-7 cells and also in tumors derived from these cells, suggesting that Bcl-2 may be an indirect target of miR-21.

The discrepancy between gene expression and protein abundance data suggests that, in spite of the previously observed co-regulation of specific miRNA-122 isomiRNAs and fas in trout [ 14, 15] and the observed concurrent decrease of fas in miRNA-122 inhibited mammalian models [ 11], fas, at the level of gene expression, may not be an indirect target of miRNA-122 in rainbow trout.

Recently, Sun et al. demonstrated that MMP3 is an indirect target of miR-200 factingZeb1 axis56 acting on the downregulation of MMP3 via Zeb1/phosphorylated-SMAD3 Zeb1/phosphorylated-SMAD3 interaction56

We investigated the ability of beta-catenin to regulate a PAI-1 reporter, and found that PAI-1 is an indirect target.

We know that the genes encoding laminin subunits α1 and α2 are direct Rest target genes [11] and γ1 is an indirect target since it is regulated by miR-124, which is a direct Rest target gene [42].

This occurs without a change in the EBS1 mRNA stability, indicating that EBS1 is an indirect target of NMD and it may be targeted by NMD-regulated transcription factors.

AMPK is an indirect target of a number of drugs besides metformin.