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There may be an extra risk for those who inherit one copy, but it was too small to measure.
Combining CYP2D6 inhibitors (like haloperidol) with metoclopramide could therefore potentially be an extra risk factor for developing serotonergic toxicity, because of its moderate low affinity to some postsynaptic 5HT receptors, when a patient has already been given other serotonergic drugs.
Similar(58)
But Dr. Goldstein and others said since there was an extra risk in using the procedure on tonsils because they are very close to the carotid artery, which carries blood to the brain.
The study is one of the biggest to look at the consequences from abortion and found that there was an extra risk, but only for women having their first child who had undergone three or more abortions.
He said: "Although we don't know for sure what caused such a tragic death, we know that working excessive hours, especially night shifts, is an extra risk to health.
The absence of resources is an extra risk to the project, and it should be recorded as such in the first project plan.
So on top of the normal risks of injecting new capital into leveraged entities with trillions of dollars of housing exposure, there was an extra political risk that all that capital could be wiped out at any time by an executive decision at 1500 Pennsylvania Avenue.This explanation I like (having given it here and here).
Under the CRisch model of Figure 1a, all individuals with >650 risk alleles get the disease, so above 650 risk alleles there is no effect of an extra risk allele.
It's an extra tool for "risk management," Mr. Hawley said.
Exploration of the IMC is an extra procedure that carries an additional risk of intra and post-operative complications and a less satisfactory cosmetic outcome.
The U.S. EPA has used an extra risk of 10% as a default (with the exception of developmental toxicity data, where an extra risk of 5% has been applied), and the EFSA also recommends a default BMR (extra risk) of 10% for quantal data, with modification based on statistical or toxicological considerations as needed (EFSA 2009a).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com