Sentence examples for be an efficient target from inspiring English sources

As we observed MALT1-API2 to be an efficient target of its own E3 ubiquitin ligase activity, our data suggest that this inherent instability of MALT1-API2 prevents its accumulation and renders a potential effect on MALT lymphoma development via destabilization of BCL10 unlikely.

We propose SAG-UPS to be an efficient target for potential future development of immunomodulators.

Hence, SAG-UPS was proposed to be an efficient target for developing therapeutics against autoimmune diseases and cancers.

In conclusion, we report that, like GBM, medulloblastoma cell lines also express IL-4R, which appears to be an efficient target for cpIL4-PE.

However, that belief over-simplifies this complex disorder, and there are old as well as recent indications that the adaptive immune system is also of major pathophysiological importance in RA, and it may also be an efficient target for RA therapy [ 13, 14].

CYP51 (sterol 14α-demethylase) is an efficient target for clinical and agricultural antifungals and an emerging target for treatment of Chagas disease, the infection that is caused by multiple strains of a protozoan pathogen Trypanosoma cruzi.

As MALT1-API2 is very unstable being an efficient target of its own E3 ubiquitin ligase activity, this suggests that its protein level in MALT lymphoma might be too low to affect BCL10 stability and localization.

Thus, the sdi1 locus is an efficient target for ectopic integration of genetic constructs.

Thus, the IGS region is an efficient target for typing B. hermsii into 1 of the 2 genomic groups.

In addition, palindromic sequences have the potential to form cruciform configurations, which are an efficient target for RAG-mediated transposition [ 51].

The present study provides the first evidence that CD146 plays a pro-fibrotic role by facilitating canonical Wnt-mediated fibroblast activation in the lesion skin, and CD146 might be an efficient therapeutic target for SSc.