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One can only assume that the loss of the parent can also be an early trigger for the problem.
Thus, increased lipid infusion and/or plasma FFA appears to be an early trigger for multiple pathways leading to atherogenesis, independent of FFA-induction of muscle or liver insulin resistance.
Translocation of gut microbiota, particularly endotoxins or lipopolysaccharides (LPSs) on the surface of gram-negative bacteria to the systemic circulation, has been proposed to be an early trigger of inflammation and obesity (8).
Exogenous phosphate was depleted before nitrate, and these results indicated that the depletion of exogenous phosphate might be an early trigger for lipid accumulation that is magnified upon nitrate depletion.
As intracellular Ca2+ increase is one of the earliest events following neuronal activation during learning, our results suggest Ca2+ could be an early trigger of the cellular cascades leading to de novo gene expression-dependent LTM formation.
Other proposed factors include elevated plasma free fatty acids concentrations, which appears to be an early trigger for multiple pathways leading to atherogenesis in non-diabetic healthy subjects [ 45], and elevated fetuin-A levels which are associated with an increased risk of myocardial infarction and IS in the general population [ 46].
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Wang P, Xu TY, Guan YF, Zhao Y, Li ZY, Lan XH, et al. Vascular smooth muscle cell apoptosis is an early trigger for hypothyroid atherosclerosis.
In fact, PLK1 is an early trigger for G2/M transition and supports the functional maturation of the centrosome in late G2/early prophase.
In the EAE model, the initial activation of resident tissue MPs (microglia) is believed to be an important early trigger for the accumulation of MPs derived from inflammatory MOs (Ajami et al, 2011).
The anoxic depolarization is an early event triggering neuronal damage in brain ischaemia.
We detected p38MAPK phosphorylation in MT103-infected cells mainly at early time points post infection, suggesting that this is an early event necessary to trigger the subsequent apoptotic machinery.
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