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Based on its well-established use as a lipid-lowering agent and efficacy when combined with many antidiabetes and/or lipid-lowering therapies, colesevelam may be an appropriate agent for use throughout the type 2 diabetes continuum, including in high-risk patients (with prediabetes) as well as late in the disease.
In terms of the involvement of 5-HT in bronchial carcinoids, SFN can be an appropriate agent for carcinoid therapy as it has been reported to reduce the expression of 5-HT receptors including 5-HT2, 5-HT3 and serotonin transporter (SERT) as well as to affect the release of 5-HT in Caco-2 cells [ 31].
Similar(58)
AcAc is an appropriate agent to prepare transparent thin films; its presence led to formation of transparent thin film but fabrication of smaller particles in presence of AcAc decreases the conductivity of thin films.
Nitrofurantoin is an appropriate agent because of low resistance levels in the community and relatively low cost.
As such, it is an appropriate agent for studying how parenterally transmitted viruses move within and between NHP populations, and from NHP to human populations.
Here, we show that methotrexate is not an appropriate agent to be used in patients with MLH1 deficient tumours as no differential selectivity is observed (Fig S1C of Supporting Information).
However, an important concern is the highly variable and unpredictable inter-individual PKs for cephalosporins and piperacillin and whether these drugs can be considered an appropriate agent to use as initial empirical therapy for critically ill patients with severe sepsis and septic shock, particularly in those with potentially less susceptible Gram-negative bacterial strains.
The antibiotic gentamicin seems to be an appropriate and active agent to support tissue healing burdened by infection processes.
These results indicate that UVA activates Nox1-based NADPH oxidase to produce ROS that stimulate PGE2 synthesis, and that Nox1 may be an appropriate target for agents designed to block UVA-induced skin injury.
Well-controlled wurtzite CIS hexagonal plates are obtained when an appropriate agent is added.
Multiple groups have shown that tumor shrinkage may not be an appropriate endpoint for evaluating anti-angiogenic agents, because restrictions in tumor microvasculature can occur without affecting tumor size [17], [18].
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