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Precipitated fibrin is present at the onset of demyelination in the LPS lesions [ 26] and is known to be an additional trigger for microglia activation in inflammatory conditions [ 1].
Next to the previously described overexpression of the oncogenic proteins SKI and SnoN (Medrano, 2003; Poser et al, 2005), an increase of BAMBI expression could be an additional trigger in the functional switch of TGF β in malignant melanoma.
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Van Eijden, a veteran of the German sprint system, feels that Pendleton's retirement has been an additional trigger for James's rapid progress.
Because AMPK is activated by low intracellular energy stores, could weight loss be an additional clinically relevant trigger?
The increase in ADIPOR1 mRNA in obese controls may be an additional compensatory mechanism triggered by the decreased adiponectin levels in obese and type 2 diabetic patients.
Indeed, high levels of sFlt-1 after delivery may be an additional factor that triggers PPCM after preeclampsia [ 15], a feature that is currently investigated in larger PPCM collectives.
These results suggest that in many cases, binding of MyoD1 by itself is not sufficient to promote the transition to an active enhancer, and it is plausible that an additional trigger is required to facilitate the removal or acquisition of a specific factor that co-occupies the enhancer with MyoD1.
However, perceived popularity was an additional significant trigger factor in urban youth, and family interactions was an additional significant trigger factor in rural youth.
We assumed that the failure to induce LTP by agonist application was either because there was the need for an additional trigger, in addition to NMDAR activation, or because LTP required NMDARs to be activated in a manner that was hard to reproduce by exogenous application of an agonist.
We hypothesize that oestrogen depletion increases the susceptibility of tissues in the joint for changes, but an additional trigger is needed to develop osteoarthritic changes.
Clearly, all of the findings support the idea that TRAIL plus an additional trigger is required to promote efficient apoptosis in primary hepatocytes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com