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Thus, increased gene expression of an adenylyl cyclase may be an additional contributing factor to increased cAMP levels in ADPKD.
Chronic subclinical inflammation may be an additional contributing factor in the intertwined processes of repeated fluid removal and cardiac stress [ 15, 16].
Indeed, infrequent monitoring may be an additional contributing factor to the low rate of cure in our cohort compared with the literature.
Moreover, early fatty degeneration of the rotator cuff [ 9], induced by periods of pain and inactivity, might be an additional contributing factor to the reduced shoulder muscle strength in our patient group as well as asymptomatic rotator cuff tears [ 38].
On the basis of these results, as well as the established link between endosomes and the regulation of NMJs (Bruneau and Akaaboune, 2006), we hypothesized that NMJ abnormalities (1) could be an additional contributing factor in MTM disease pathogenesis and (2) could be subject to modification via drug treatment.
Taken together, our findings suggest that in general, both cortical HPτ pathology and WM SVD may lead to the development of WMH; however, in neurodegenerative diseases such as AD, WMH are primarily associated with cortical HPτ pathology, while WM SVD may be an additional contributing factor.
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HPV might then be an additional factor contributing to malignant transformation of the skin.
Host immune response to cattle lice is poorly understood, and hypersensitivity may be an additional mechanism contributing to damage.
39 An increased sensibility 40 41 while expecting Christmas combined with a depressed mood in the face of death might be an additional factor contributing to this phenomenon.
CCND1 amplification might simply be an additional mechanism contributing to high levels of CCND1 overexpression observed in oestrogen receptor-positive tumours, through a simple gene dosage effect.
Thus, it is reasonable to speculate that DAPK1 silencing may be an additional mechanism contributing to malignant progression by conferring resistance to apoptosis.
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