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So how can the bill be amended to reduce the risk of history repeating itself?
Former information minister Sherry Rehman has also received death threats for introducing a private members bill calling for the blasphemy laws to be amended to reduce its misuse.
The university sector generally supports deregulation of fees, but wants the bill to be amended to reduce the scale of government funding cuts and protect students from the effect of compounding interest on Hecs loans.
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To appease Republican opponents, the legislation was amended to reduce Missouri's maximum state-financed unemployment benefits to 20 weeks instead of 26.
Because of these observations, the study protocol was amended to reduce the dose of CC-930 from 100 mg BID to 100 mg QD for the three patients who remained in the study on treatment.
In 1975, Senate Rule 22 was amended to reduce the cloture threshold from 67 Senators to 60. Filibusters and cloture votes happened relatively few times during each Senate Session.
Therefore, the study was amended to reduce the temsirolimus dose from 25 mg to 20 mg i.v. weekly.
Upon identification of the MTD, the protocol was amended to reduce topotecan dosing from 5 to 3 days.
Another finding is that panobinostat was overall poorly tolerated and was about one-third of patients who required at least one dose reduction, even after the protocol was amended to reduce the starting dose by half.
However, after treatment of the first 40 patients, of whom 20 were randomised to the combination treatment arm, the protocol was amended to reduce the dose of IL-2 3 IL-2 3days per week, 2 weeks on and 2 weeks off, because of the onset of AEs.
In addition, during evaluation of 240 mg BID as the tablet formulation in the present study, the protocol of the ongoing Western phase III trial of tivantinib in advanced HCC (METIV-HCC) was amended to reduce the starting dose of tivantinib from 240 mg BID to 120 mg BID, because patients who received 240 mg BID as the tablet formulation had an increased incidence of neutropenia.
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