DNA methylation status in genomic regions not directly participating in gene silencing, such as the edges of CpG islands, may be altered at the precancerous stage before the alterations of the promoter regions themselves occur (22).
As expected and described for few genes [ 4, 56], most of the genes were found to be altered at higher cumulative incidence than as reckoned by individual alterations (Fig. 5).
Of alterations not defined before, UBR5, ZNF384 and TERT were found to be altered at higher frequency at 32, 19, 16%%, respectively.
The sense, and reality, of mutually assured destruction will not be altered at all.
In reality, his contribution was limited to a few concluding scenes which had to be altered at the last moment.
A recent paper showed that 62 genes could be altered at once, demonstrating the power of the technology.
However, goal-directed movements can be altered at any time, if for instance, the target location is changed during execution.
No longer are they committed to choices made on a rainy location; with CGI it can all be altered at a later date.
6. Collarless The collar will be either too tight or big - this can be altered at the back of the neck.
Complicating enforcement further, synthetic drugs can be altered at a molecular level by chemists such that they fall outside current legal definitions of prohibited substances.
Materials scientists and researchers have realized that the mechanical properties of materials can be altered at the fundamental level, i.e. the atomic-scale.
