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The anti-tumour effects of GHRH antagonists can be also mediated through direct mechanisms.
The inverse association may be also mediated through weight gain or obesity, which is an established risk factor for T2D.
Indeed, we found a strong increase of miR-34a exosomal preparation, as compared with uninfected cultures (Supplementary Figure S2), suggesting that its regulatory effects could be also mediated through a cell non-autonomous mechanism.
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In addition to inhibiting GPCR-mediated physiological processes, the activity of GRK5 is also mediated through non-GPCR pathways.
The post-transcriptional regulation of Tfrc (transferrin receptor 1) by iron is also mediated through the IRE/IRP system [39].
As Ime2 is required for NDT80 transcription [36], our results suggest that the effect of Ime2 is also mediated through Ndt80.
The tumor regression by Noscapine and combination was also mediated through decreased expression of VEGF and correlated very well with our VEGF expression results obtained with western blots of tumor lysates (Fig. 4D).
Food aversions are also mediated through culturally informed practices.
It remains to be determined whether other metabolic effects of FGF21 are also mediated through adiponectin.
Using immunofluorescent analysis, we determined that the tumor size decrease was also mediated through apoptosis.
In this study, DR5 upregulation was also mediated through CHOP induction.
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