Sentence examples for be allosteric modulators of from inspiring English sources

Compared to CASR, much higher extracellular calcium concentrations are needed to activate GPRC6A [8], [8], and some studies suggest that cations may only be allosteric modulators of GPRC6A [9], whereas others show cation-dependent activation of GPRC6A [3].

Magnolol and analogues have been shown to be allosteric modulators of GABAA receptors, thus their binding site does not overlap with the one for GABA, muscimol, bicuculline or gaboxadol.

Some endogenous steroids, as progesterone and allopregnanolone, are allosteric modulators of GABAA chloride ion channels [ 29– 329.

DHEAs are negative allosteric modulators of the GABAA receptor (Majewska 1992) with paradoxical effects in depression and anxiety as DHEA supplementation has been reported to improve well being and depression in elderly subjects and to be anxiolytic (Wolkowitz et al. 1999; Van Broekhoven and Verkes 2003; Morales et al. 1994; Yen et al. 1995; Wolkowitz et al. 1995).

Our group recently published a theoretical comparison of machine learning techniques for the identification of compounds that are predicted allosteric modulators of the mGluR5 glutamate response (68).

3α-reduced neuroactive steroids (3α, 5α-tetrahydroprogesterone - THP; 3α, 5β-THP; 3α, 5α-tetrahydrodeoxycorticosterone) are potent allosteric modulators of GABAA-receptors [ 38, 39].

Calcimimetic agents like NPS R-568 are positive allosteric modulators of the CaSR, which potentiate the effects of the CaSR by interacting with the 7-transmembrane region of the receptor and inducing conformational changes.

Calcilytic agents (e.g. NPS 2143) that are negative allosteric modulators of the receptor act in a similar manner, desensitizing the receptor, and reducing its affinity to its ligands [14,15].

In accordance with previous studies of pRpp synthetases (Prs) from other organisms, Mt-PrsA was strongly inhibited by the presence of ADP, which has been shown to be an allosteric modulator of this class of enzymes (Switzer and Sogin 1973; Gibson et al. 1982; Arnvig et al. 1990; Eriksen et al. 2000; Willemoes et al. 2000).

Certain metabolites of progesterone (e.g., allopregnanolone) are potent positive allosteric modulators of GABAA receptors, and produce sedative-like effects in laboratory animals.

It has recently been shown that allosteric modulators of transporters may have the potential to inhibit their functioning [ 19– 23].