Bootstrap analysis was used to compute the adjusted probability that a human gene was affected in cancer but not in normal ESTs [23], [24].
Promoters and enhancers of many genes, whose expression is affected in cancer development, bear TRE capable of binding the Fos and Jun transcription factors.
As a consequence, HP1α should now be taken into account in fundamental cancer research to obtain a comprehensive picture of how heterochromatin domains are affected in cancer cells and contribute to tumourigenesis.
Because acyl-CoAs represent important intermediates of lipid metabolism that are affected in cancer [ 29], we report the concentrations of both long-chain as well as short/medium-chain acyl-CoAs from the liver tissue.
The DNA methylome and hydroxymethylome are affected in cancers.
To probe whether cNHEJ is affected in cancers with mutational RB1 loss, we assessed reporter repair in SAOS-2 osteosarcoma cells, which carry an inactivating mutation in RB1 (Hellwinkel et al., 2005) and U2OS osteosarcoma cells, which have wild-type RB1.
Alternatively, they could share molecular mechanisms without sharing mutation targets, i.e., similar pathways may be affected in both cancers despite different mutated genes.
It has been reported to be affected in various cancers including HNC [ 17– 19] and is emerging as a new therapeutic target.
Rb1 was previously found to be affected in specific thyroid cancer cells upon h NAA10 depletion (52).
