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Food intake control may be affected by polymorphisms in the genes encoding taste receptors and a number of peripheral signaling peptides such as insulin, leptin, ghrelin, cholecystokinin, and corresponding receptors.
Individual response to pesticide exposure may be affected by polymorphisms in genes affecting pesticide metabolism.
Host range may also be affected by polymorphisms in the host receptor gene that codes for cellular receptors.
One potential problem with the use of expression microarrays is that oligonucleotide hybridization could be affected by polymorphisms located within probes (Gilad, Rifkin et al. 2005).
Moreover, vitamin K recycling in the liver may be affected by polymorphisms such as that of the aforementioned VKORC1 gene [ 8– 10].
While previous estimations of variability suggested that only about 10% of the miRNAs will be affected by polymorphisms [ 10], our study reports 44% have variants in the analyzed populations.
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The capacity to effectively detoxify ROS is affected by polymorphisms of ROS detoxification genes [ 27, 28].
We are not aware of similar analyses in plants, but they are in general agreement with an analysis of EST and cDNA data, which estimate that 21% of human AS genes are affected by polymorphisms that alter the relative abundances of alternative isoforms [ 41], and with RNA-Seq analysis of 6 human individuals that estimate that between10%and30 30% AS events show individual-specific variation [ 1].
This is in general agreement with an analysis of EST and cDNA data that estimated that 21% of human AS genes are affected by polymorphisms that alter the relative abundances of alternative isoforms [ 41], and an RNA-Seq analysis of different tissues in 6 human individuals, which estimated that between10%and30 30% AS events show individual-specific variation [ 1].
Tissue n-3 LCPUFA levels are affected by polymorphism in fatty acid desaturase encoding genes and by gender, and it may also depend on other dietary aspects.
Therefore, this mechanism to control blood lipids may be affected by genetic polymorphisms such as A-3826G pofymorphism of UCP-1 gene [ 27].
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