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Clinical trials are currently using VX-770 and VX-809 together in an attempt to improve therapeutic effects and will be advanced to phase 3 testing.
Our computational approach, particularly when expanded to include additional antibiotics such as bedaquiline, can form part of the international collaborative effort to determine which antibiotics and combinations should be advanced to phase 2 and 3 clinical trials [ 10] and inform strategies to include immune-modulators in TB treatment [ 49].
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As in 4- and 6-month-old 3xTgAD mice, daily temperature rhythms in these older animals were also consistently phase advanced relative to Non-Tg control mice (genotype F1,38: 18.79, P<0.001; Bonferroni post-tests, P<0.001 at 8 and 10 months and P<0.01 at 9 months; Fig. 2A C,E).
The E-ELT (European extremely large optical/infrared telescope) in Cerro Armazones (20 km away from Cerro Paranal) is in advanced design phase and will be the largest optical telescope in the world.
Ninety patients with advanced ESCC who were admitted to the phase II clinical trials in the Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute from March 2007 to March 2014 were finally eligible for present study and the corresponding tissues and clinical data were collected.
Gefitinib (ZD1839, Iressa) and erlotinib (OSI-774, Tarceva) are in advanced phase II/III development and other agents are in phase I/II trials Table 1.
Clinical testing of reovirus through a strong translational programme is well advanced following phase I and II studies as a single agent [ 15- 17] and in combination with cytotoxic chemotherapy [ 18- 20] or radiotherapy [ 21].
ZEPLIN III is an advanced two-phase xenon detector designed to search for weakly interacting massive particles (WIMPs), such as the neutralino, which make up the dark matter halo of the Galaxy.
The C111G single nucleotide polymorphism (SNP) was also reported to be associated with advanced sleep phase syndrome (ASPS) in Japanese ASPS families (Satoh et al. 2003).
In particular, epothilones are in advanced phases of clinical development [ 214, 215].
Alectinib is in advanced phases of development and was recently approved in Japan for the treatment of ALK-positive NSCLC.
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