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Perhexiline can be administered continuously to humans for many years, with mean plasma concentrations of ∼2 µM without any significant adverse effects [80], [84].
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Citalopram was administered continuously to adult male C57BL/6J mice via osmotic minipump for 2 days, 14 days or 28 days.
When Dox is administered continuously to P; N; Npc1 −/− mice starting at P77, neuron loss commences.
HRT should be administered continuously, without intervals, to avoid sudden estrogen deprivation and the consequent possible onset of migraine[5].
Treatment with albendazole (ABZ) is recommended to be administered continuously in courses of 3 to 6 months or longer, depending on cyst stage and patient characteristics [ 4, 13– 15].
Nebraska's death penalty law calls for a current of electricity to be administered continuously until the prisoner dies, Judge Hippe said.
Different from our study, TAM was planned to be administered continuously lifelong at the dose of 30 mg/day.
Most importantly, if these findings can be translated into an in vivo cancer chemoprevention strategy, it suggests that the active agent may not need to be administered continuously.
This definition simplified data collection and is nearly as efficient as a measure that required the same antimicrobial drug to be administered continuously during the interval (2 ).
Recent in-vitro and animal data suggest that enhanced tumor-specific cytotoxicity can be achieved with far less collateral damage to normal surrounding tissues if PDT is administered continuously at a lower dose rate for extended periods of time.
To maintain the effect of adenosine over longer periods, it should be administered continuously, for example, via a syringe pump.
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