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This regimen can be adjusted by increasing the dose to 10 mg/kg and/or shortening the intervals between doses to as often as every 4 weeks to optimize patient response [ 37].
The level of difficulty can be adjusted by increasing the difficulty of the perceptual (eg, increasingly complex forms have to be correctly identified), cognitive (eg, increasingly difficult mathematical questions) or motor challenges (eg, child has to do more repetitions or work with higher load).
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Since a proportion of patients may partially include the effects of ill-health on income in health state valuation [34] [36], utilities were adjusted by increasing their value by 4.5%, as derived from Sendi and Brouwer [35].
Resistance was adjusted by increasing the tension of pulling forces of the elastic bands.
Trough levels <200 ng/ml on day −1 were adjusted by increasing the CsA dose by at least 25%.
Each unit cost was adjusted by increasing or decreasing its value by 25 and 50%, while holding all other variables constant to assess the effect on threshold.
Resistance was adjusted by increasing the tension of pulling forces on the resistance training machine and participants started with 15 exhausting repetitions in the first weeks (Borg's Rate of Perceived Exertion = RPE: 10 12).
Patients obtained volume-controlled ventilation (8 ml/kg bw) and the minute volume was adjusted by increasing the respiratory rate but maintaining a PaCO2 level between 35 and 45 mmHg.
ACSF was adjusted by increased Ca++ concentrations (126 mM NaCl, 26 mM NaHCO3, 3 mM KCl, 2.5 mM CaCl2, 1.3 mM MgSO4, 1.25 mM NaH2PO4 and 10 mM glucose, saturated with 95%O2/5%% CO2).
Those results well indicate that the ECL of Pt (II) complexes with planar core structures can be adjusted by simply increasing the steric hindrance.
The response time of the holding mechanism can be adjusted by reducing or increasing the number of teeth on the driver or follower gears.
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