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This potential unmeasured confounding could not be adequately controlled for in the current analyses, although health status, physical activity and comorbidities were taken into account.
Many studies were not adjusted for potential confounders, and many confounders cannot be adequately controlled for in vastly different study arms.
However, because the male and female data were not from the same study and the time and sex analyses were evaluated separately, inter-study confounding factors can not be adequately controlled for.
Similar(57)
The reported increase of circulating adhesion molecules in patients with OSA remains controversial because confounders such as cardiovascular risk factors and left ventricular function have not been adequately controlled for.
Individual socioeconomic variables were adequately controlled for.
Furthermore, practice activity and referral patterns have not been monitored concurrently and important prognostic factors have not always been adequately controlled for when measuring patient outcomes.
Finally, it may be that the relationship is due to residual confounding from other factors, either measured or unmeasured, which have not been adequately controlled for.
Any major change to the significance of predictor would suggest that a factor had not been adequately controlled for and could bias the results.
Maternal ethnicity, BMI, and smoking status are known to affect cffDNA levels, but these confounding factors have not been adequately controlled for in earlier studies.
Median levels of SBP, SDP, and LDL cholesterol in these cohorts were also indicative of a significant proportion of them being adequately controlled for blood pressure and lipid targets (Table 2).
Since we are unable to rule out the existence of information bias in the measurement of these variables, it is impossible to assure that all variables have been adequately controlled for confounding.
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