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178 The effect of sleep extension in subsets of short sleepers on metabolism can be addressed in randomized controlled trials.
Whether a pharmacological increase in CI and SvO2 improves the overall outcome in human septic shock treated with vasopressin analogues should be addressed in randomized controlled clinical trials.
This question cannot feasibly be addressed in randomized controlled trials, because the focus of such trials is on direct comparison of two regimens rather than on comparison of one regimen at different times during the course of a patient's disease.
Not all items are applicable to all studies, e.g., as some items can only be addressed in randomized controlled trials, they will always have a higher level of evidence.
Regarding the present data, one might speculate that selenium supplementation might improve survival and/or clinical course of patients after successful CPR, but this has to be addressed in randomized controlled trials.
The trials provide a model for designing response-guided treatment algorithms in other malignancies, such as lung, head and neck and ovarian cancer, for which induction treatment has a potential role and the algorithms need to be addressed in randomized phase III trials.
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We therefore sought to investigate how decisions of withholding/withdrawing life-sustaining therapies are addressed in randomized controlled trials in critically ill patients.
However, two major gaps regarding treatment targeting the cholinergic system that have previously not been addressed in randomized trials relate to the short duration of follow-up for treatment effects and the lack of information on specific cognitive domains.
These issues are to be addressed in a randomized phase II trial of amifostine given subcutaneously or via intravenous bolus in non-small cell lung cancer patients undergoing chemoradiation treatment.
This issue should be addressed in a randomized clinical trial.
This question will need to be addressed in future randomized trial.
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