These pathophysiological considerations demonstrate the complexities of PPV, which should be addressed in further studies.
The physiological and pathophysiological functions of P2Y5 other than in hair growth will have to be addressed in future studies.
Despite considerable progress in describing the pathophysiological consequences of Mecp2 mutations in mice, crucial gaps remain that must be addressed in order to establish optimal models for preclinical evaluation of potential RTT therapeutics.
These different approaches to treat AGE accumulation and the pathophysiological relevance of AGE formation in sepsis and mechanical ventilation need to be addressed in future studies using either soluble RAGE or blockers of AGE formation.
The present results are hypothesis generating, encouraging further studies on the pathophysiological relation between copeptin and IGFBP-1 and whether copeptin per se is a factor to be addressed in order to improve the outcome in these patients.
The pathophysiological role of TDP-43 has been addressed in cell culture and animal models using mutation, alteration or expression of disease-specific variants of TDP-43 and its homologs in worms, flies, zebrafish, mice and rats (11, 12, 14).
In the light of the previous data on increased HNE levels in OA articular tissues, particular interest should be addressed to the pathophysiological role of this aldehyde in OA.
In the light of previous data on decreased GSTA4-4 actinity in patients with OA, particular interest should be addressed to the pathophysiological role of this enzyme in OA development.
The issue of what is voluntary about FMSS is one of the most difficult questions to be addressed by any pathophysiological theory.
These roadblocks can be addressed by (i) characterizing trans-diagnostic, translational pathophysiological dimensions as potential treatment targets, (ii) efficiency, accountability and, transparency in approaches to the clinical trials process, and (iii) leveraging recent advances in genetics and in vitro phenotypes.
