The flood model was additionally validated for surge extents with available inundation maps from FEMA76 (Fig. SI 7) and shows very good agreement in spatial extents and total flooded area.
The normalized model was additionally validated through comparison of probability levels of transformed data with the probability of occurrence of actual (crude set) data points.
Open reading frames attributed to heavy metal resistance were additionally validated by sequence comparison with NCBI-NR using BLAST program.
Where minimum value imputation analysis was performed, our results were additionally validated by a stability analysis imputing changing fractions of the minimum values obtained for each response, which confirmed our main analysis.
Cases in Germany were additionally validated by diagnostic records.
Our findings were additionally validated by Sanger sequencing of the respective genomic loci.
Interaction interfaces in complexes are additionally validated using the PISA algorithm.
The caryophyllene peak was additionally validated with the mass spectrum of a standard compound.
The upregulation of MMP9 and IGF1 was additionally validated with qPCR (data not shown).
These results were additionally validated in vivo by tumorigenesis and liver metastasis experiments.
