Approximately one-third of our non-WNK patients with FHHt remain without a molecular diagnosis raising the possibility that there may be additional regulators of thiazide-sensitive distal nephron sodium trafficking which remain to be discovered.
The two other Drosophila family members, Drep-2 and -3, were suggested to be additional regulators of apoptosis, solely based on in vitro interactions (Inohara and Nuñez, 1999; Park and Park, 2012).
As pluripotency factors are additional regulators of Xist (Navarro et al., 2008; Nesterova et al., 2011), we assessed the consequences of the different knockdowns on the Xist-related pluripotency network in female ESCs.
The putative panregulon varies in sizes from 101 (FixK) to 6 (NolR) orthologous groups (i.e. genes); since some of the regulated targets could be part of an operon or be additional regulators, the actual size of the predicted panregulon is definitely under-estimated.
However, the transcript abundance of regulatory proteins is often very low and not all regulator transcripts can be reliably measured in this experimental system, so there may be additional regulators key to these responses.
The logarithmic increase in miR-142 in both wt and p300tg mice between 2 and 3 months suggests that there may be additional positive regulators of miR-142 that act during later stages of myocardial maturation associated with reproductive maturity.
Although there may be additional undescribed regulators of STAT3 within the gene lists examined, our results further emphasize the likely direct actions of STAT3β on STAT3α via heterodimer formation rather than indirect actions through downstream transcriptional differences.
p19Arf and p16Ink4a that are encoded by the Ink4a/Arf locus, are two additional regulators of neural stem cell proliferation.
There may be additional transcriptional regulators within the coding sequence of either gene that have not been identified.
In this respect, analysis of double mutants (with one mutation being the rat1-1 mayation) may be instrumental in finding additional regulators of TERRA stability and, furthermore, of TERRA transcriptional activation.
In conclusion, our data provide for the first time evidence that Hes1 is an additional regulator of thyroid development and differentiation (Figure 8), beside the known thyroid enriched transcription factors such as Nkx2-1, Foxe1, and Pax8: Hes1 maintains an adequate pool of thyroid progenitor cells via a p57-independent mechanism, determining normal thyroid size.
