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The aim of our study was to review the evidence on the accuracy of instruments for identifying abused children during any stage of child maltreatment evolution before their death, and to assess if any might be adapted to screening, that is if accurate screening instruments were available.
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The existing progesterone assays could be adapted to screen chemicals for effects specific to breast tissue.
With minor modifications and optimization, this platform can be adapted to screen for novel therapeutic agents against infectious agents.
The aim of this systematic review was to examine the evidence on accuracy of tools proposed to identify abused children before their death and assess if any were adapted to screening.
Besides, different high-throughput genome editing platforms are offering remarkable resources that can be adapted to screen for potential therapeutic targets in combination with disease models.
Our strategy could be adapted to screen for mutants in CRISPR-Cas9 transgenic organisms.
The platform could be adapted to screen for compounds that target other types of tumour, or even for other diseases that can be modelled in Drosophila larvae.
Finally, the demonstrated ability of our high-throughput yeast-based screening assay to identify both activators and inhibitors of K2P2.1 (TREK-1) suggests that this platform can be adapted to screen for regulators of other K2Ps.
As key physiological processes are well conserved from flies to humans, the spliceosensor approach could be adapted to screen for compounds that target other types of human splicing alterations.
Our methods can also likely be adapted to screen antibodies, for which the HA tag and the anti-HA antibody can be switched with the Fc region of antibodies and immunoreagents against the Fc region.
His books Class Trip and The Adversary were adapted to screen by directors Claude Miller and Nicole Garcia respectively, and have figured in the Cannes competition in previous years.
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CEO of Professional Science Editing for Scientists @ prosciediting.com