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We hypothesized that the Prdm gene family may also significantly participate in the development of the mammalian nervous system as this family meets the molecular criteria to be active in neurogenesis.
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In both rodent and human adult brain, neurogenesis is active in two distinct zones of the forebrain: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) [1] [5].
Adult neurogenesis is active in some specific niches in the human brain, and this process is dysregulated in neurodegenerative disorders 97.
None are active in management.
In our example, Emx2 is active during early neurogenesis in ventricular zone progenitors of the developing cortex and switched off during mid-neurogenesis (Cecchi, 2002).
The subventricular zone of the lateral ventricles [ 26] and the dentate gyrus [ 33] are active sites of neurogenesis in adult humans.
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