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New active catalytic systems in which the formation of highly dispersed metallic species is favored are found to be active at lower reaction temperatures.
Thus we hypothesized that the DNMT inhibitors AZA and DAC could have a targeted effect on AML1/ETO-positive leukemic cells, and be active at lower doses.
myo-Inositol 1,3,4,5,6-pentakisphosphate (InsP5, 2) has also been reported to have similar antiproliferative effects and to be active at lower concentrations (<50 μ m).[ 5] The mechanisms underlying the effects of applying InsP6 or InsP5 to cells (reviewed in ref. [ 4]) are not clear.
In porcine leukocytes, prophenins are amidated at the C-terminus [ 40, 41], and this extra positive charge may contribute to the binding of negatively charged targets; therefore, it is expected that the amidated version of the peptide tested in this study will be active at lower concentrations against T. vaginalis.
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CauloGA is active at lower substrate concentrations and at lower temperatures compared with the thermophilic GAs reported.
De novo catalysis is due mainly to copper, although iron and other metals are active at lower rates.
Thus, the development of new catalysts that are active at lower temperature, yet still stable at periodic high temperatures, will be vital.
In spring, wolverines showed restricted movement patterns around rendezvous sites at high elevations by day, whereas during the night animals were active at lower elevations.
The second group of sub-elite referees (n = 19, mean age 32.8 years, SE = 1.8, range 23 50) was active at lower competitive levels and had no refereeing experience at the professional level (Table 1).
Although both peptides were found to be bactericidal against a variety of clinical isolates with different antibiotic resistance profiles, hep-20 was active at lower concentrations than hep-25, in most of the cases.
For each drug, the EC50 was reduced in triple combination compared to the EC50 as a single agent, indicative that each drug was active at lower concentrations (greater potency).
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CEO of Professional Science Editing for Scientists @ prosciediting.com