Sentence examples for be active as monotherapy from inspiring English sources
These and other agents in this class can be shown to be active as monotherapy in refractory ovarian cancer (Finkler et al, 2001) and may have synergism with platinum and taxanes.
Oxaliplatin is active as monotherapy in patients with BTC [ 7].
Epidermal growth factor receptor-targeted monoclonal antibodies are active as monotherapy beyond second-line treatment.
Phase II trials evaluated bevacizumab on recurrent platinum-resistant EOC and, unlike in other solid tumours, it was active as monotherapy (Burger et al, 2007; Cannistra et al, 2007).
We show that SM83 is active as monotherapy in vivo on human and murine cancer cells that are refractory to SMs in vitro, and demonstrate that these cells die through a non-apoptotic, TNF-dependent mechanism.
In this dosing schedule, Belinostat is not active as monotherapy, suggesting further investigations of different dosing schedules or in combination with other chemotherapeutics.
In conclusion, our data demonstrate that the SM SM83 is active in monotherapy by promoting inflammation and immunogenic cell death.
In the phase 1 and 2 trials in CRPC, ipilimumab was active whether used as monotherapy 25, 28 or with other interventions such as radiotherapy 26, docetaxel 27, or other immunotherapeutics with different mechanisms of action 29– 35.
The CRPC studies of ipilimumab to date suggest that the agent is active in prostate cancer as monotherapy or in combination with radiotherapy, docetaxel, or other immunotherapeutics, and that the adverse event profile is as expected given the safety data in advanced melanoma.
Be physically active as well.
