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Furthermore, MAPKs can also be activated through the upstream activation of HER2/neu or RAS.
The activation of STAT3 (signal transducer and activator of transcription) is triggered via binding to the ObRl-exclusive box 2 motive, while the MAPK (mitogen-activated protein kinase) pathway can be activated through the junxtamembrane box 1 motive, which is present in all isoforms.
These two enzymes thus appear to be activated through the comprehensive effects of several activators with low specificities, physiologically, although it is possible that they have unknown activators with higher specificities.
Hence, in the context of a class C GPCR homodimer, G proteins might be activated through the ligand-bound subunit (cis-activation) and/or through the other subunit (trans-activation).
Stress- activated ion channels on the cell surface can be activated through the forces transmitted by the integrins to the channel elements, either directly or through the cytoskeleton.
The experiment lags slightly behind the simulation result at around 5 or 10 minutes, but this is reasonable given that that in the simulation the level of active Akt is set directly whereas in the experiment it must be activated through the IIS pathway, with a delay of the order of a few minutes.
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Ishida H, Li K, Yi M, Lemon SM. p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells.
RSK2 is one of four RSK serine-threonine kinases that are activated through the mitogen-activated protein kinase (MAPK) signal transduction pathway.
11 The activity of mTOR also is regulated by cellular stress when intracellular adenosine triphosphate (ATP) levels are depleted, the adenosine monophosphate-activated protein kinase is activated through the tumor suppressor LKB1 (serine threonine kinase 11).
The inactive zymogen is cleaved into active PO by a serine protease, which is activated through the sequential cleavage and activation of other serine proteases [ 46].
The pathway enrichment among genes is activated through the same edges by introducing the activation model.
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