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However, as previously reported, the cleavage of un-cleaved CASP3 (called pro-CASP3) into active C-CASP3 could be activated through multiple pathways (Porter and Janicke, 1999).
In a tumor microenvironment, Snail can be activated through multiple pathways, including HIF1, HIF2, and Notch in response to hypoxia as well as NF-κB and TGF-β in response to inflammation [28,29].
We can not rule out the hypothesis that Akt could be activated through multiple mechanisms in BLCs, and not only through low PTEN expression.
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Recent studies have revealed how these receptors are activated through multiple allosteric interactions between subunit domains.
In oxidative stress p53 protein is activated through multiple posttranslational events including phosphorylation [ 46].
Because BRAF is activated through multiple mechanisms in the majority of thyroid cancers (see Figure 1), there has been an interest in targeting BRAF for potential therapeutic benefit in patients with thyroid cancer.
ATG9 has been shown to self-oligomerize and was also detected in an asymmetric distribution on autophagic membranes., Therefore, we included a process wherein PtdIns3P- or PtdIns 3,5 P2-bound WIPtdIns 3,5 P2-boundto form a complex [ATG9-WIPI1/2-PtdIns3P or ATG9-WIPI1/2-PtdIns(3,5)P2] and thengages9 within this complex is ATG9vatod through multiple steps.
Here we demonstrate that these various silver cluster species (templated on the polycytosine heads of different lengths) can also be activated through guanine proximity, leading to multiple NCB activation colors.
Lieblein, J. C. et al. STAT3 can be activated through paracrine signaling in breast epithelial cells.
The ad can also be activated through in-text ads.
Its protein product cannot be activated through Tyr phosphorylation.
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