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Recently, it has been recognized that the unfolded protein response (UPR) can also be activated through hypoxia (11).
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In a tumor microenvironment, Snail can be activated through multiple pathways, including HIF1, HIF2, and Notch in response to hypoxia as well as NF-κB and TGF-β in response to inflammation [28,29].
We discuss in particular remote ischaemic postconditioning whereby endogenous brain tolerance can be activated through hypoxia/reperfusion stimuli started immediately after the index hypoxic-ischaemic insult.
We compared the increase of gene expression under anoxia (<0.01% oxygen) produced by 3, 6, and 9 copies of hypoxia-responsive elements (HRE) from the erythropoietin gene (Epo), which are activated through the transcriptional complex hypoxia-inducible factor 1 (HIF-1).
Their expression was described to be activated by hypoxia, involving Hypoxia Inducible Factor-1 (HIF-1 -dependent HIF-1 -dependent], [8].
Our results show that mast cells survive and can be activated during hypoxia.
Thus, in these models mast cells might not be activated directly by hypoxia or the reperfusion, but through indirect mechanisms.
Autophagy can be activated after exposure to hypoxia or to chemotherapeutic drugs including taxol.
A variety of metabolic pathways can be activated in response to hypoxia.
17 In the present study, we used radiotherapy and hypoxia-mediated gene therapy to construct an AND gate genetic circuit through combination of the heat shock elements with the radiation response promoter cArG6 and tested whether the constructed AND gate could be activated by radiation and hypoxia stimuli.
Nrf2 can be activated by oxidants produced during hypoxia [ 23].
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