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Schematically, NF-κB can be activated through either the classical or the alternative pathway.
(D' ) A minority of genes can be activated through either MEK/ERK or PI3K signaling in response to PDGF or FGF, indicating a degree of plasticity in intracellular pathway usage.
The CIS workflow would be activated through either a patient diagnosis or the tumour board decision.
1, 2 The coagulation system includes both pro- and anticoagulant proteins and can be activated through either the intrinsic or the extrinsic pathway.
Gelatinases are secreted into the extracellular matrix in their inactive, pro- form where they can be activated through either a cysteine switch or shift in the prodomain mediated by integrins and laminin in basement membranes and structural proteins, such as vimentin [ 25].
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The C system is activated through either of three pathways, initiated by e.g. microorganisms, immune complexes (IC), and tissue injuries.
Since these 16 genes are common to both Btk- and Itk-dependent transcriptomes it seems likely that the corresponding promoters could be activated through signaling components controlled by either pathway.
As Elliott describes, much of this power is manifested through the physical realm and can be activated through intense physical activity.
Furthermore, MAPKs can also be activated through the upstream activation of HER2/neu or RAS.
Stress- activated ion channels on the cell surface can be activated through the forces transmitted by the integrins to the channel elements, either directly or through the cytoskeleton.
Lieblein, J. C. et al. STAT3 can be activated through paracrine signaling in breast epithelial cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com