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In an open surgical site, these products can be activated into a fibrin gel that offers additional local antihemorrhagic and sealing properties.
Capacity of macrophages to be activated into a pro-inflammatory state by chemokines and cytokines generally declines with aging (Sebastian et al., 2009).
Methyl parathion is a weak acetylcholinesterase inhibitor, but it can be activated into a more potent metabolite, its oxon derivative, methyl paraoxon (O,O-dimethyl O-p-nitrophenyl phosphate), by a desulfuration reaction catalyzed by cytochrome P-450 [ 5].
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Integrins contained within focal adhesions are activated into a high-affinity conformation by extracellular binding and tension [15].
This is in contrary to the fact that acyclovir is activated into a human herpes virus (HHV) DNA polymerase inhibitor exclusively by HHV kinases.
Once LCFA cross the membrane, most are activated into an LC-acyl-CoA (LCACoA) primarily via ACSL1 (activation shown by small red dots).
ABL1 is activated into an oncogene and forms a fusion gene with break point cluster (BCR) gene due to missense mutations within the ABL1 kinase domain.
In order to be fully active, CPT-11 needs to be activated into the active compound SN-38 (7-ethyl-10-hydroxycamptothecin) by carboxylesterase (CE) enzymes (Tsuji et al, 1991; Satoh et al, 1994).
Consequently, there is a reduction in the number of elements that are available to be activated into the A1 state, which results in a reduction in responding.
What signal(s) force the compatible pollen tube to cease elongation and how the growing tip of the tube is maintained in a plastic state that can be activated into further extension growth (Taylor and Hepler 1997) remain interesting questions.
CPT-11 can be considered as a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase.
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