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Rho is implicated in carcinogenesis, as has been found to be activated in various human cancers [12], [13].
In normal cells, the p53 protein can be activated in various ways.
The serine/threonine protein kinase, Akt, plays critical role in mammalian cell survival and has been shown to be activated in various cancers including BCa [ 37, 38].
On the other hand, cells can be activated in various ways in response to stress during cell development, mainly to maintain the balance between cell death and cell proliferation [ 94].
Nuclear factor- κB has been reported to be activated in various tumours, such as human leukaemia and lymphoma, the lung, breast, colon and pancreatic carcinomas (Rayet and Gelinas, 1999; Karin and Lin, 2002 Wu and Krall, 2005; Braeuer et al, 2006).
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Noticeably, the MAPK/ERK is activated in various carcinomas and its activation is believed to promote carcinogenesis.
UPR is activated in various types of tumors, cell lines, and tumor models.
The nuclear enzyme poly(ADP-ribose) polymerase (PARP) is activated in various forms of circulatory shock.
Previous studies have demonstrated that the PI3K/Akt pathway is activated in various tumor MDR cell types.
Chang's group observed that the ESC-like module is activated in various human epithelial cancers.
Stat3 is one of the transcription factors for cyclin D1, and Stat3 is activated in various cancers, including ovarian cancer.
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