Multiple lines of evidence indicate that PKC-δ is activated in distinct ways that regulate cellular functions such as the control of growth, differentiation and apoptosis [ 6].
The findings on mitigation, however, point to a much different dynamic and signal that support for mitigation and adaptation are activated in distinct ways.
Taking these data together suggests that there are different means by which the classic and alternative NF-κB pathways are activated in distinct subgroups of nodal PTCLs, and that these warrant further investigation.
We observed that insulin signaling proteins in human skeletal muscle in vivo are activated in a distinct temporal pattern within 30 min after an OGTT.
We have previously demonstrated that, although both primary endothelial cells and the hepatoma cell line Huh7 respond to infection by hantaviruses by up-regulating ISGs, we observed several differences in cellular entry and transcription factor requirements that suggested a divergent PAMP and/or PRR axis had been activated in these distinct cell types [33], [34].
2 Its BH3-only members, which include Bad, Bim/Bod, Bik/Blk/Nbk, Hrk/DP5, Puma/Bbc3, Noxa, Bmf and Bid, are essential initiators of apoptosis that are activated in response to distinct developmental cues and cytotoxic signals.
Accordingly, for each unique spatio-temporal sequence a slightly different distribution of neurons is activated in M1 which in turn cause distinct voxel activity patterns for each of the studied sequence combinations (Kamitani and Tong, 2005; Kriegeskorte et al., 2006).
BH3-only proteins are known to play a key role in regulating Bax activation with distinct family members being activated in a cell type and stimulus-specific manner.
Importantly, it has been shown that BAX is activated in a stepwise fashion, where two distinct biochemical steps mediate membrane translocation and oligomerization (Kim et al, 2009).
Importantly, PRL does not restore CPT1 enzyme activity in normal breast epithelial cells in which CPT1A, LKB1, or AMPKα-1 are knocked down, suggesting that distinct pathways are activated in normal and malignant cells.
