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Crabp1 can be activated by thyroid hormone (T3/T4) binding of the holo-thyroid hormone receptors/retinoid receptors that in turn bind to the thyroid response element (TRE) located approximately 1 kb upstream of the crabp1 basal promoter.
Expression of MyoD in SKM can also be activated by thyroid hormone (3,3′,5-tri-iodothyronine or T3) and the T3-response element (TRE) has been located to the −337 to −309 region of the proximal promoter [ 46].
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The RET gene can be activated by somatic rearrangements in papillary thyroid carcinoma or by point mutations in sporadic and familial (MEN2) medullary thyroid carcinomas.
For example, ret and trk genes were found to be activated by gene rearrangements in human papillary thyroid carcinomas.
As a ligand dependent transcription factors, nuclear receptors (NR) can be activated by important molecules such as steroidal hormones, endogenous hormones, glucocorticoids and thyroid hormones [1, 2].
Reporter gene analysis found that the promoter region of TG, TPO, and TSHR could be activated by the forced expression of either Pax-8 or TTF-1 in the papillary thyroid carcinoma cell line NPA (Ros et al, 1999).
Earthlink's software, however, must be activated by users.
—Matt Kemp could be activated by Friday.
Ranzi, V. et al. The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.
This potential may not be limited to just PTCs with BRAF-activating mutations because BRAF and the entire RAF kinase family are activated by other oncogenes involved in thyroid cancer development, in both PTC and follicular carcinomas.
Consider, for instance, the following sentence Notch pathway is activated by MAPK signalling and influences papillary thyroid cancer proliferation.
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