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As Mst1 can be activated by increased H2O2 levels, inactivation of Prdx1 resulted from the activated Mst1 might enforce a feedback stimulation system to prolong or intensify Mst1 activation.
JNK1 is known to be activated by increased PKCδ levels in cells [ 38].
AMPK can be activated by increased FA supply, increased AMP ATP ratio, and ischemia.
In contrast, thapsigargin treatment promotes translocation of AIF (apoptosis inducing factor) to the nucleus, a pathway known to be activated by increased intracellular Ca2 +.
Addition of ranolazine markedly improved diastolic tension under basal conditions but to a greater extent under frequency-induced stress, suggesting that CaMKII may be activated by increased Ca levels (and hence Ca overload) thereby activating late INa (Fig. 2).
The results in Figure 3E-H thus show that Pcat can be activated by increased [Ca2+]i alone, without dehydration, and that K+ permeabilization itself has no effect on Pcat.
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Intervening protein sequences (inteins) from extremely halophilic haloarchaea can be inactive under low salinity but could be activated by increasing the salt content to a specific concentration for each intein.
Activation of CaMKKs by Ca2+/calmodulin provides an alternate pathway by which AMPK can be activated by increasing intracellular Ca2+ levels, independently of AMP.
Modifying the neurons in a specific hemilineage so that they expressed a heat-sensitive channel called dTRPA1 allowed that hemilineage to be activated by increasing the temperature.
Relevant to our findings in breast cancer cells, Bruce et al. (2007) have shown that fatty acid β-oxidation may nevertheless be activated by increasing the level of CPT1 protein in both isolated mitochondria and intact skeletal muscle [ 33].
Evidence indicates that microglia are activated by increased synaptic activity [8], [9] and that their signaling can also influence synaptic activity [10] [13].
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