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By this we mean that a large number of genes involved in a signaling pathway related to a certain trait may be activated by expression of upstream genes.
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Phenylpropanoid pathway genes were activated by expression of the maize C1 and R transcription factors in soybean seed, which decreased genistein and increased the daidzein levels with a small overall increase in total isoflavone levels.
Western blotting verified the K-ras isoform was activated by expression of Src (Fig. S2).
Cells whose reporter gene has been activated by expression of WAP-Cre appear in late pregnancy.
In this way, the RNAi machinery is activated by expression of GFP dsRNA but there is no mRNA target present.
In the absence of augmented IGF1R expression, IGF-signaling pathways could potentially still be activated by elevated expression of other components of the IGF1-signaling pathway.
Since STAT1 is activated by both type I and Type II IFN stimulations, we therefore examimed whether intracellular STAT1 signaling could be activated by intracellular expression of the modified STAT1-CC molecule to overcome viral resistance to IFN.
Previous studies suggest that JNK-mediated death can be activated by eiger expression driven by a pan-eye promoter GMR-Gal4 (GMR>eiger) in Drosophila.
Map3k1 can be activated by heart-restricted expression of G αq, a heterotrimeric G protein subunit, in transgenic mice.
Reporter gene analysis found that the promoter region of TG, TPO, and TSHR could be activated by the forced expression of either Pax-8 or TTF-1 in the papillary thyroid carcinoma cell line NPA (Ros et al, 1999).
The NPPA and NPPB genes can also be activated by glucocorticoids and increased expression has been associated with hypertrophy.
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