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In terms of decision-making tasks such as ours, the insula has also been found to be activated by changes in reward contingencies [21]).
In this case, the nuclease could be activated by changes in the conformation of the β-hairpin.
We previously proposed that a constitutively expressed but inactive TF (e.g., MYB) could be activated by changes in redox status at 10°C and this possibly leads to rapid induction of its target TFs (e.g., TGA10) occurring at phase-1 [ 17].
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The alternative hypothesis was that epizootic events result from an increased pathogen load in host animals after the pathogens have been activated by changes in the environment, changes in host population behaviour, or shifts in abundance and distribution patterns of host (e.g., prairie dog) and vector (e.g., flea) of the disease.
SM22α is a cardiac specific protein whose promoter is activated by changes in actin cytoskeletal dynamics but not growth factor signaling since it is responsive to myocardin (a MAL family member) but not TCF [34].
In contrast, the anterior temporal lobe and intraparietal sulcus are activated by changes in acoustic scale across categories.
The HIF pathway is activated by changes in cellular oxygen levels and has significant impacts on the regulation of gene expression patterns in cancer cells.
Several Ca2+-permeable channels are activated by stimuli that freely cross membranes: capsaicin and related endogenous compounds are lipophilic and activate TRPV1 (75), and several TRP proteins (TRPV1−4, TRPM2, TRPM8, and TRPA) are activated by changes in temperature (76).
Two major apoptotic pathways have been characterized, one of which is activated by changes in mitochondrial permeability (intrinsic pathway) and the second, triggered by cell surface death receptors engaging specific ligands (extrinsic pathway) [ 1].
Future work is needed to improve the ability of mixtures models to account for the homeostatic processes that are activated by changes in both tissue and serum TH concentrations.
With all this in mind, sperm TRPM8 channels may be activated by temperature changes within the range encountered in the female tract.
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