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Partial inhibition might mean that B cells can still be activated by certain pathogens in this setting while epratuzumab (anti-CD22) inhibits activation of autoreactive B cells.
It has been reported that ATM can also be activated by certain dietary components (e.g. resveratrol in red wine, benzyl isothiocyanate (BITC) in papaya and certain vegetables and the micronutrient selenium) [83] [85] that are known to have anti-aging or anticancer activities.
Moreover, TRP channels in free nerve endings of the trigeminal system might only be activated by certain metabolites.
It has also been suggested that ligands can be activated by certain modifications during the recycling process [ 3– 6].
Other defense pathways mediated by ethylene (ET) and jasmonic acid (JA) also can be activated by certain pathogens and herbivores [ 2, 3].
Besides vanilloid compounds, TRPV1 can alternatively be activated by certain other painful stimuli, including protons, ethanol, and noxious heat (>42 °C).
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BSIH cannot bind iron until it is activated by certain reactive oxygen species to active chelator SIH.
In addition to PET and fMRI, which show which areas of the brain are activated by certain tasks, researchers also use diffusion tensor imaging (DTI), which shows the neural pathways that connect different brain areas, thus providing insight into how different areas interact.
APCs are activated by certain cytokines such as IL-1β and TNF-α produced by keratinocytes.
Importantly, the two K2P channels are activated by certain anaesthetics, membrane stretching, intracellular acidosis, and by heat (Maingret et al, 1999a, 1999b, 2000; Patel et al, 1999).
Although GPR55 is activated by certain cannabinoids, the low sequence homology with CB receptors (10 15%) argues against a clear affiliation to the historically established cannabinoid receptor family, despite higher sequence homologies within the conserved regions [ 3].
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